应北京大学化学学院唐淳教授的邀请，RIKEN BDR生物分子动态结构实验室的组长，著名学者Ichio Shimada 教授，于2021年10月29日下午，在线上为北京大学的师生们做了题为“Function-Related Dynamics of Membrane Proteins by NMR”的兴大报告。

More

2021年9月30日，中科科学院上海有机化学研究所研究员刘聪老师应唐淳教授邀请，与化学学院举办了题为“α-Synuclein病理性聚集与帕金森病”的长葛未名创新工场讲座。

More

为庆祝2021年教师节的到来，Tanglab的成员为唐老师进行准备了颈椎按摩器。

颈椎按摩器对长期伏案工作的人员有很好的按摩作用，可以放松神经、血管与颈部肌肉。之后，唐老师邀请实验室成员体验了按摩器，体验了被电的酥酥麻麻的滋味。

Chinese Academy of Sciences

Innovation Academy of Precision Measurement of Sciences and Technology

30 W. Xiao Hong Shan, Wuhan 430071 China
Email: tanglab@wipm.ac.cn, tanglab@apm.ac.cn

Peking University

College of Chemistry and Molecular Engineering & Center for Life Sciences

292 Chengfu Road, Beijing 100871 China
Email: Tang_Chun@pku.edu.cn

Publications

77 Xuhui Yan, Kai Pei, Zeyuan Guan, Feiqing Liu, Junjun Yan, Xiaohuan Jin, Qiang Wang, Mengjun Hou, Chun Tang & Ping Yin, “AI-empowered integrative structural charac terization of m⁶A methyltransferase complex” Cell Research (2022) https://doi.org/10.1038/s41422-022-00741-8

76 Jian-Hua Wang, Yu-Liang Tang, Zhou Gong, Rohit Jain, Fan Xiao, Yu Zhou, Dan Tan, Qiang Li, Niu Huang, Shu-Qun Liu, Keqiong Ye, Chun Tang, Meng-Qiu Dong & Xiaoguang Lei, “Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers” Nat Commun 13, 1468 (2022). https://doi.org/10.1038/s41467-022-28879-4

75 Yingxue Ma, Haozheng Li, Zhou Gong, Shuai Yang, Ping Wang, and Chun Tang, 2022,”Nucleobase Clustering Contributes to the Formation and Hollowing of Repeat-Expansion RNA Condensate” J. Am. Chem. Soc. https://doi.org/10.1021/jacs.1c12085

74 Xu Dong, Ling-Yun Qin, Zhou Gong, Sanbo Qin, Huan-Xiang Zhou, and Chun Tang,2022.”Preferential Interactions of a Crowder Protein with the Specific Binding Site of a Native Protein Complex” J. Phys. Chem. Lett.: 792–800https://doi.org/10.1021/acs.jpclett.1c03794

73 Czaplewski, C., et al. (2021). “Recent Developments in Data-Assisted Modeling of Flexible Proteins.” Frontiers in Molecular Biosciences 8(1306).https://doi.org/10.3389/fmolb.2021.765562

72 Fu, W., et al. (2021). “Discovery of a Novel Androgen Receptor Antagonist Manifesting Evidence to Disrupt the Dimerization of the Ligand-Binding Domain via Attenuating the Hydrogen-Bonding Network Between the Two Monomers.” Journal of Medicinal Chemistry 64(23): 17221-17238.https://doi.org/10.1021/acs.jmedchem.1c01287

71 Kogut M, Gong Z, Tang C, Liwo A. (2021) Pseudopotentials for coarse‐grained cross‐link‐assisted modeling of protein structures
M Kogut, Z Gong, C Tang, A Liwo Journal of Computational Chemistry 42 (29), 2054-2067 Journal of Computational Chemistry, doi.org/10.1002/jcc.26736

More

Meng Ling-shen (孟令屾)

E-mail: 1600011738@pku.edu.cn

My name is Meng Ling-shen, a student from PKU CCME. It’s my pleasure to be a member of Tang lab.

Xuzheng Wang(王旭正)

E-mail: 623858043@stu.pku.edu.cn

I’m Xuzheng Wang. Graduated from Xiamen University, I joined Tanglab in 2020. Now I am studying in College of Chemistry and Molecular Engineering, Peking University. It’s a great honor to meet everyone in Tanglab.

Chen Jingru (陈镜如)

E-mail: chenjingru@pku.edu.cn

Hi, I’m Chen Jingru, I completed my undergraduate study in physics at Central China Normal University, and now I am studying for a PhD at Peking University. Tanglab is a laboratory full of passion, creativity and love, I’m going to be a hot-wired, heat-seeking person, riding the wave, pushing the envelope in a sea of interdisciplinary subjects. I will make every effort to perform my duty, make my own contribution, and grow with Tanglab family side by side.

Zihan Li(李梓焓)

E-mail: chemlzh@pku.edu.cn

Hello, I’m Zihan Li, an undergraduate student from Peking University, and now a member of Tang’s Lab. I’m pleased to work together with senior schoolmates in Tang’s Lab, and I’m ready to do more researches in solution NMR and protein dynamic structures.

Xinyuan Lu(卢信源)

E-mail:2101110403@pku.edu.cn

Hello, my name is Xinyuan Lu, and I graduated from PKU CCME with a bachelor’s degree in 2021. I’m honored to have been accepted into Tang Lab to pursue a Ph.D. My present research focuses on the development of probes for solvent paramagnetic relaxation enhancement (sPRE).

Kai Pei（裴凯）

E-mail:2106596201@pku.edu.cn

I am Kai Pei. I graduated from Hua Zhong Agriculture University. I am major in Biochemistry and Molecular Biology. Now I work in Tang Lab as a research assistant.

Yida Jiang(江意达)

Hi, I’m Yida Jiang, graduated in PKU CCME, and continue my Ph.D. degree in Tang Lab. My recent work will be posted on jiangyida.top.

• Name：Yida Jiang
• E-Mail: jiangyida@pku.edu.cn
• Wechat: jiang_yida
• QQ: 476540183
• Github: https://github.com/DF-Master

Xinghe Zhang(张兴赫)

E-mail:chemxhzhang@stu.pku.edu.cn

My name’s Zhang Xinghe. Majored in chemistry, I obtained my bachelor’s degree in Wuhan University. In the next five, or at least five years, I wish to make some ferocious activity (zhěng diǎn hěn huó) in the field of biological physics, protein characterization especially.

Yuhao Li(李煜昊)

I’m Yuhao Li . I obtained my Bachelor’s degree from Peking University at 2022. And now I am continuing my career in PKU CCME and studying from my PhD in Tang lab. It’s a great pleasure to do my research in such a passionate and fun team.

Jin Li(李金)

E-mail: chemlij@stu.pku.edu.cn

Hello! My name is Li Jin, graduated from Sichuan University. Now I’m studying for a PhD at Peking University. I feel privileged to be a member of Tanglab. My research interest focuses on the structure and dynamics of proteins, providing insight into potential drug discovery.

Haoyang Deng(邓皓洋)

E-mail: denghaoyang@pku.edu.cn

I am Haoyang Deng. I am studying in College of Molecular Engineering, Peking University, and I will be major in chemical biology. Now I am working in Tang Lab for undergraduate research.

More

Shangxiang Ye(叶尚祥)

Email: yeshangxiang@wipm.ac.cn

Hi, I am Shangxiang Ye. I obtained my Bachelor degree from Central China Normal University Now I am studying for a PhD in Tang lab. It’s my pleasure to be a member of Tang lab. And my main research work is to study the molecular mechanism of PINK1/Parkin-mediated mitophagy.

5月7—8日，以“强体魄，庆百年”为主题的北京大学第28届体育文化节暨2021年田径运动会在五四体育中心举行，全校万余名师生参加了本届运动会，运动会主要分为传统田径项目和趣味运动项目两部分。

More

Lanthanoid tagging via an unnatural amino acid for protein structure characterization

Lanthanoid pseudo-contact shift (PCS) provides long-range structural information between a paramagnetic tag and protein nuclei. Here we report two lanthanoid probes, DTTA-C3-yne and DTTA-C4-yne, which can be conjugated to an unnatural amino acid pAzF in the target protein via azide-alkyne cycloaddition. The DTTA-based lanthanoid tags are associated with large magnetic susceptibility tensors owing to the rigidity of the tags.

Reference: J Biomol NMR, 2017, 67:273-282.

More